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BRCA1 BRCA1 DNA repair associated [ Pongo pygmaeus (Bornean orangutan) ]

Gene ID: 129017314, updated on 26-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo pygmaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonPyg2-v2.0_pri (GCF_028885625.2) 19 NC_072392.2 (76139152..76234036, complement)
RS_2023_04 previous assembly NHGRI_mPonPyg2-v1.1-hic.freeze_pri (GCF_028885625.1) 17 NC_072390.1 (72502308..72597189, complement)

Chromosome 19 - NC_072392.2Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene next to BRCA1 gene 2 protein Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene collagen, type I, alpha 1a-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
Breast cancer type 1 susceptibility protein homolog
RING-type E3 ubiquitin transferase BRCA1
breast cancer type 1
breast cancer type 1 susceptibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885625.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

Genomic

  1. NC_072392.2 Reference NHGRI_mPonPyg2-v2.0_pri Primary Assembly

    Range
    76139152..76234036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054457711.2 → XP_054313686.2  breast cancer type 1 susceptibility protein homolog isoform X5

  2. XM_063656679.1 → XP_063512749.1  breast cancer type 1 susceptibility protein homolog isoform X1

  3. XM_054457710.2 → XP_054313685.2  breast cancer type 1 susceptibility protein homolog isoform X5

  4. XM_063656683.1 → XP_063512753.1  breast cancer type 1 susceptibility protein homolog isoform X3

  5. XM_063656684.1 → XP_063512754.1  breast cancer type 1 susceptibility protein homolog isoform X2

  6. XM_063656678.1 → XP_063512748.1  breast cancer type 1 susceptibility protein homolog isoform X1

  7. XM_063656702.1 → XP_063512772.1  breast cancer type 1 susceptibility protein homolog isoform X17

  8. XM_063656690.1 → XP_063512760.1  breast cancer type 1 susceptibility protein homolog isoform X8

  9. XM_054457705.2 → XP_054313680.2  breast cancer type 1 susceptibility protein homolog isoform X3

  10. XM_054457701.2 → XP_054313676.2  breast cancer type 1 susceptibility protein homolog isoform X1

  11. XM_063656698.1 → XP_063512768.1  breast cancer type 1 susceptibility protein homolog isoform X16

  12. XM_063656685.1 → XP_063512755.1  breast cancer type 1 susceptibility protein homolog isoform X5

  13. XM_063656697.1 → XP_063512767.1  breast cancer type 1 susceptibility protein homolog isoform X15

  14. XM_054457707.2 → XP_054313682.2  breast cancer type 1 susceptibility protein homolog isoform X3

  15. XM_063656696.1 → XP_063512766.1  breast cancer type 1 susceptibility protein homolog isoform X14

  16. XM_063656680.1 → XP_063512750.1  breast cancer type 1 susceptibility protein homolog isoform X2

  17. XM_063656695.1 → XP_063512765.1  breast cancer type 1 susceptibility protein homolog isoform X13

  18. XM_054457700.2 → XP_054313675.2  breast cancer type 1 susceptibility protein homolog isoform X1

  19. XM_054457708.2 → XP_054313683.2  breast cancer type 1 susceptibility protein homolog isoform X6

  20. XM_063656693.1 → XP_063512763.1  breast cancer type 1 susceptibility protein homolog isoform X11

  21. XM_063656687.1 → XP_063512757.1  breast cancer type 1 susceptibility protein homolog isoform X7

  22. XM_063656686.1 → XP_063512756.1  breast cancer type 1 susceptibility protein homolog isoform X5

  23. XM_063656682.1 → XP_063512752.1  breast cancer type 1 susceptibility protein homolog isoform X4

  24. XM_063656691.1 → XP_063512761.1  breast cancer type 1 susceptibility protein homolog isoform X9

  25. XM_063656692.1 → XP_063512762.1  breast cancer type 1 susceptibility protein homolog isoform X10

  26. XM_063656681.1 → XP_063512751.1  breast cancer type 1 susceptibility protein homolog isoform X3

  27. XM_054457703.2 → XP_054313678.2  breast cancer type 1 susceptibility protein homolog isoform X2

  28. XM_063656688.1 → XP_063512758.1  breast cancer type 1 susceptibility protein homolog isoform X8

  29. XM_063656689.1 → XP_063512759.1  breast cancer type 1 susceptibility protein homolog isoform X8

  30. XM_054457737.2 → XP_054313712.2  breast cancer type 1 susceptibility protein homolog isoform X23

  31. XM_054457735.2 → XP_054313710.2  breast cancer type 1 susceptibility protein homolog isoform X22

  32. XM_054457697.2 → XP_054313672.2  breast cancer type 1 susceptibility protein homolog isoform X1

  33. XM_054457733.2 → XP_054313708.2  breast cancer type 1 susceptibility protein homolog isoform X21

  34. XM_063656705.1 → XP_063512775.1  breast cancer type 1 susceptibility protein homolog isoform X25

  35. XM_054457729.2 → XP_054313704.2  breast cancer type 1 susceptibility protein homolog isoform X20

  36. XM_063656703.1 → XP_063512773.1  breast cancer type 1 susceptibility protein homolog isoform X24

  37. XM_054457727.2 → XP_054313702.2  breast cancer type 1 susceptibility protein homolog isoform X19

  38. XM_063656704.1 → XP_063512774.1  breast cancer type 1 susceptibility protein homolog isoform X24

  39. XM_063656694.1 → XP_063512764.1  breast cancer type 1 susceptibility protein homolog isoform X12

  40. XM_063656700.1 → XP_063512770.1  breast cancer type 1 susceptibility protein homolog isoform X18

  41. XM_063656699.1 → XP_063512769.1  breast cancer type 1 susceptibility protein homolog isoform X17

RNA

  1. XR_010124717.1 RNA Sequence

  2. XR_010124718.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6J6J0.1 GenPept UniProtKB/Swiss-Prot:Q6J6J0

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