BRCA1 BRCA1 DNA repair associated [Nomascus leucogenys (northern white-cheeked gibbon)] - Gene

Summary

Gene symbol: BRCA1
Gene description: BRCA1 DNA repair associated
See related: EnsemblRapid:ENSNLEG00000011944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Nomascus leucogenys
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
103	current	Asia_NLE_v1 (GCF_006542625.1)	Unplaced Scaffold	NW_022095770.1 (121755..206152)
102	previous assembly	Nleu_3.0 (GCF_000146795.2)	Unplaced Scaffold	NW_003501569.1 (1973911..2103417, complement)

NW_022095770.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:454458 (e-PCR)
- UniSTS:157440

GDB:454462 (e-PCR)
- UniSTS:157441

GDB:454466 (e-PCR)
- UniSTS:157442

PMC280658P1 (e-PCR)
- UniSTS:272396

PMC280658P2 (e-PCR)
- UniSTS:272397

RH79896 (e-PCR)
- UniSTS:90392

PMC139147P1 (e-PCR)
- UniSTS:270874

PMC13918P1 (e-PCR)
- UniSTS:270877

D17S1323 (e-PCR)
- UniSTS:150080

BRCA1_4046 (e-PCR)
- UniSTS:464465

G60034 (e-PCR)
- UniSTS:137300

BRCA1 (e-PCR)
- UniSTS:262743

PMC110706P1 (e-PCR)
- UniSTS:270193

PMC310899P11 (e-PCR)
- UniSTS:272801

PMC310899P12 (e-PCR)
- UniSTS:272802

PMC310899P2 (e-PCR)
- UniSTS:272804

PMC310899P3 (e-PCR)
- UniSTS:272805

PMC310899P5 (e-PCR)
- UniSTS:272806

PMC310899P6 (e-PCR)
- UniSTS:272807

PMC310899P8 (e-PCR)
- UniSTS:272808

G10044 (e-PCR)
- UniSTS:1986

GDB:626905 (e-PCR)
- UniSTS:158402

D17S1198 (e-PCR)
- UniSTS:56291

GDB:388557 (e-PCR)
- UniSTS:157159

GDB:388674 (e-PCR)
- UniSTS:157161

GDB:389047 (e-PCR)
- UniSTS:157164

GDB:389054 (e-PCR)
- UniSTS:157165

GDB:631944 (e-PCR)
- UniSTS:158446

GDB:391365 (e-PCR)
- UniSTS:157168

GDB:454227 (e-PCR)
- UniSTS:157424

GDB:454278 (e-PCR)
- UniSTS:157425

GDB:391818 (e-PCR)
- UniSTS:157170

GDB:454349 (e-PCR)
- UniSTS:157426

GDB:391825 (e-PCR)
- UniSTS:157171

GDB:454353 (e-PCR)
- UniSTS:157427

GDB:391832 (e-PCR)
- UniSTS:157172

GDB:454372 (e-PCR)
- UniSTS:157428

GDB:391839 (e-PCR)
- UniSTS:157173

GDB:454381 (e-PCR)
- UniSTS:157429

GDB:391846 (e-PCR)
- UniSTS:157174

GDB:454421 (e-PCR)
- UniSTS:157431

GDB:391860 (e-PCR)
- UniSTS:157176

GDB:454425 (e-PCR)
- UniSTS:157432

GDB:391867 (e-PCR)
- UniSTS:157177

GDB:454429 (e-PCR)
- UniSTS:157433

GDB:391874 (e-PCR)
- UniSTS:157178

GDB:454433 (e-PCR)
- UniSTS:157434

GDB:391881 (e-PCR)
- UniSTS:157179

GDB:454437 (e-PCR)
- UniSTS:157435

GDB:454441 (e-PCR)
- UniSTS:157436

GDB:454446 (e-PCR)
- UniSTS:157437

GDB:454450 (e-PCR)
- UniSTS:157438

GDB:454454 (e-PCR)
- UniSTS:157439

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dosage compensation by inactivation of X chromosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of BRCA1-BARD1 complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: breast cancer type 1 susceptibility protein

Names: breast cancer type 1 susceptibility protein homolog

NP_001295597.1

EC 2.3.2.27

XP_030663935.1

EC 2.3.2.27

XP_030663936.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308668.1 → NP_001295597.1 breast cancer type 1 susceptibility protein

See identical proteins and their annotated locations for NP_001295597.1

Status: PROVISIONAL

Source sequence(s)

KM017627

UniProtKB/TrEMBL

A0A075VSA7, G1RN17

Related

ENSNLEP00000014631.2, ENSNLET00000015362.3

Conserved Domains (4) summary

smart00292
Location:1758 → 1842

BRCT; breast cancer carboxy-terminal domain

cd00027
Location:1650 → 1724

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cd00162
Location:23 → 68

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam12820
Location:345 → 507

BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

NW_022095770.1 Reference Asia_NLE_v1 Primary Assembly

Range

121755..206152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030808075.1 → XP_030663935.1 breast cancer type 1 susceptibility protein isoform X1

UniProtKB/TrEMBL

G1RN17

Related

ENSNLEP00000042201.2, ENSNLET00000048887.2

Conserved Domains (4) summary

cd16498
Location:18 → 65

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1757 → 1854

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1649 → 1745

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:345 → 507

BRCT_assoc; Serine-rich domain associated with BRCT
XM_030808076.1 → XP_030663936.1 breast cancer type 1 susceptibility protein isoform X2

UniProtKB/TrEMBL

G1RN17

Conserved Domains (4) summary

cd16498
Location:18 → 65

RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17721
Location:1757 → 1854

BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

cd17735
Location:1649 → 1745

BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

pfam12820
Location:344 → 506

BRCT_assoc; Serine-rich domain associated with BRCT