Figure 3. Comparison of standard blastp and DELTA-BLAST statistics and alignments. The match found between the human hemoglobin beta (NP_000509) a globin (YP_485375) from the purple non-sulfur bacterium Rhodopseudomonas palustris HaA2 is shown. Top panel: Protein blast results (RID: 0E4F72U7013). In the blastp alignment the conserved histidine at position 92 in the human protein is not aligned with a corresponding histidine in the bacterial sequence, and gaps are inserted into the conserved alpha helix in this region. Middle panel: Partial conserved domain alignment and structure for globin (cd01040) showing the conserved histidine (red H) residue and alpha helix (colored block). Bottom panel: DELTA-BLAST alignment (RID: 0E5RMA6X016). The DELTA-BLAST result gives a much more significant expect value and more accurate alignment for the globin domain accurately aligning the conserved histidine and preserving the alpha helix.